Piperazine is an important pharmaceutical intermediate, which is mainly used in the production of intestinal worm repellent drugs such as piperazine phosphate, piperazine citrate, Fluphenazine, Qiangtongding, Rifampicin, trimethoprim and other chemobooks. It is also used in the production of surfactants such as wetting agents, emulsifiers, dispersants, as well as plastic processing aids such as antioxidants, preservatives, stabilizers, and rubber additives.
Appearance: | Yellow or orange red transparent viscous liquid |
Structure |
![]() |
Melting Point | 109-112 °C (lit.) |
Boiling Point | 145-146 °C (lit.) |
Storage Conditions | Store below +30°C. |
Solubility | H2O: 0.1 M at 20 °C, clear, colorless |
Color | White to slightly yellow |
Form | Crystalline Flakes |
Stability | Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents. |
Odor | at 0.10 % in dipropylene glycol. ammoniacal |
Soluble | 150 g/L (20 ºC) |
Density | 1,1 g/cm3 |
purpose
Piperazine, also known as expelling roundworms, is a safe and effective anti roundworm and anti pinworm drug. China's "Veterinary Pharmacopoeia" includes piperazine citrate and piperazine phosphate. This product can paralyze roundworm muscles, prevent the worm body from attaching to the host intestinal wall, and then be excreted from the body with feces.
application
Piperazine is clinically used for intestinal Ascariasis, effective for incomplete Bowel obstruction caused by ascaris lumbricoides or early biliary Ascariasis, and also for Pinworm infection infection. Various salts of piperazine (chemically stable than piperazine) are low toxicity and effective anti roundworm drugs. In addition to roundworms, they also have certain effects on esophagostomy nematodes and pointed tail nematodes, and have been widely used in veterinary clinical practice. The repellent effect of piperazine is an anticholinergic effect on the neuromuscular junction of roundworms, thereby blocking the transmission of nerve impulses; At the same time, the function of producing succinic acid on the worm body is also blocked, resulting in paralysis of the worm body, loss of its ability to attach to the host intestinal wall, and excretion from the body through intestinal peristalsis.
Drums
IBC
Tank